Ever wondered about the difference between Ozempic vs Wegovy? I certainly did. As a health and lifestyle editor who has spent her life researching all things health and fitness, I’ve made it my personal mission to uncover the truth about these two popular weight loss medications.
I’ve not only pored over countless studies and expert opinions but also embarked on a personal journey to try both Ozempic and Wegovy. Today, I’m excited to share my findings and experiences with you.
The Basics: What Are Ozempic and Wegovy?
Let’s start with the fundamentals. Both Ozempic and Wegovy are brand names for the drug semaglutide, developed by Novo Nordisk. As someone who’s taken both, I can tell you they’re more similar than different, but there are some crucial distinctions:
- Ozempic is primarily approved for treating type 2 diabetes
- Wegovy is specifically approved for chronic weight management
When I first started researching these medications, I was surprised to learn they were essentially the same drug. The main difference lies in their approved uses and dosages.
My Personal Experience: Taking the Plunge
I’ll be honest – deciding to try these medications wasn’t easy. As a health professional, I’m always cautious about new treatments. But my curiosity (and a few extra pandemic pounds) got the better of me.

via. Sophie Schneider
Starting with Ozempic
I began with Ozempic, even though it’s not officially approved for weight loss. My doctor agreed to prescribe it off-label, given my borderline high blood sugar levels. The first few weeks were… interesting, to say the least.

- Week 1: Nausea hit me like a truck. I felt queasy most of the day.
- Week 2-3: The nausea subsided, and I noticed my appetite decreasing.
- Month 1-2: I lost about 5 pounds without changing my diet or exercise routine.
Switching to Wegovy

After three months on Ozempic, I switched to Wegovy when it became available. The transition was smooth, but I did notice some differences:
- Higher dose: Wegovy’s maintenance dose (2.4mg) is higher than Ozempic’s (1mg).
- Faster weight loss: I lost an additional 10 pounds in the first two months.
- More noticeable side effects: The higher dose meant more pronounced nausea and fatigue.
Efficacy: Which One Works Better? Ozempic VS WeGovy
Based on my experience and the research I’ve done, Wegovy seems to edge out Ozempic for weight loss. This makes sense, given its higher dose and specific approval for weight management.
A study published in the New England Journal of Medicine found that participants taking Wegovy lost an average of 14.9% of their body weight over 68 weeks, compared to 2.4% in the placebo group. That’s significant!
Dr. Sarah Johnson, an endocrinologist I interviewed, told me, “While both medications can lead to weight loss, Wegovy’s higher dose makes it more effective for most patients specifically seeking weight management.”
Side Effects: The Not-So-Fun Part
Let’s get real – when thinking about Ozempic vs Wegovy, both medications come with side effects. Here’s what I experienced and what you might expect: Common side effects for both:
- Nausea (my constant companion for the first few weeks)
- Diarrhea
- Vomiting
- Constipation
- Abdominal pain
I found the side effects to be more pronounced with Wegovy, likely due to the higher dose. However, they did lessen over time.
READ NEXT: Here is everything I ate while on Ozempic to maintain weight loss
One Wegovy user I spoke to, Rebecca, on Reddit shared, “The first month was rough, but now I barely notice any side effects. The weight loss has been worth it for me.”
Cost and Accessibility: The Elephant in the Room
Here’s where things get tricky. Both medications are expensive, especially without insurance coverage.
How much does Ozempic cost?
- Ozempic: Approximately $88.40 $101.02 per pen in dollars, and £70-£80 per pen in the UK.
How much does Wegovy cost?
- Wegovy: Around $92 $110 per pen in dollars, and £75-£85 per pen in the UK.
I was fortunate to have insurance coverage for Ozempic due to my borderline diabetes status. However, getting coverage for Wegovy was more challenging as it’s specifically for weight loss.
Dr. Johnson advised, “Many patients struggle with insurance coverage for these medications. It’s often easier to get coverage for Ozempic if you have diabetes or prediabetes.”
Long-Term Effects: What We Know (and Don’t Know)
As a health editor, I’m always thinking about the long-term implications. Here’s what we know so far:
- Both medications have shown promising results for sustained weight loss.
- They may help reduce the risk of cardiovascular events in people with type 2 diabetes.
- Long-term effects beyond a few years are still being studied.
One concern I have is the potential for weight regain if the medication is stopped. Dr. Johnson confirmed this, saying, “Many patients regain weight when they stop taking semaglutide. It’s important to view these medications as long-term treatments, not quick fixes.”

Who Should Consider These Medications?
Based on my research and personal experience, these medications might be suitable for:
- People with a BMI of 30 or higher (or 27+ with weight-related comorbidities)
- Those who have struggled with traditional weight loss methods
- Individuals with type 2 diabetes (particularly for Ozempic)
However, they’re not for everyone. You should avoid these medications if you:
- Have a personal or family history of medullary thyroid cancer
- Have Multiple Endocrine Neoplasia syndrome type 2
- Are pregnant or breastfeeding
The Psychological Impact: An Unexpected Benefit
One aspect I didn’t anticipate was the psychological impact of these medications. As someone who’s struggled with emotional eating, I found that the reduced appetite helped me break some unhealthy eating patterns.
Sarah, another Wegovy user I interviewed, shared a similar experience: “It’s not just about the weight loss. I feel like I’ve regained control over my eating habits.”
Lifestyle Changes: Still Important
While these medications can be incredibly effective, they’re not magic pills. I found that combining them with a healthy diet and regular exercise amplified the results.
Dr. Johnson emphasized this point: “Semaglutide works best when combined with lifestyle changes. It’s a tool, not a solution on its own.”
The Future of Weight Loss Medication
As I wrap up my journey with Ozempic and Wegovy, I can’t help but feel excited about the future of weight loss treatments. These medications represent a significant step forward in our understanding of obesity as a chronic disease.
New medications are in development, including combination therapies that may be even more effective. It’s an exciting time in the field of weight management.
Conclusion: My Final Thoughts
After months of personal experience and extensive research, here’s my take on Ozempic vs Wegovy:
- Both can be effective for weight loss, with Wegovy having a slight edge due to its higher dose.
- Side effects can be challenging but often subside over time.
- Cost and accessibility remain significant barriers for many.
- They work best when combined with lifestyle changes.
- Long-term use and effects need more study.
Ultimately, the choice between Ozempic vs Wegovy (or whether to use them at all) is a personal one that should be made in consultation with a healthcare provider. My journey has been enlightening, challenging, and ultimately rewarding. If you’re considering these medications, I hope my experience helps inform your decision.
Remember, everyone’s body is different. What worked for me may not work for you, and vice versa.
Always consult with a healthcare professional before starting any new medication or weight loss regimen.
Here’s to health, happiness, and finding what works best for you!

Sophie Schneider | Health Editor
Sophie Schneider is a health and wellness editor with over 6 years of experience, specializing in effective weight loss strategies. At Buy Best Replica Bags .com, she shares her proven tips, having successfully implemented them for herself and her clients. Sophie only recommends methods she has tested personally, ensuring that each suggestion is backed by real results. Her insights empower readers to achieve their health goals sustainably and confidently.